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uMMA test:

The uMMA test will reveal if the tissue is using B12.  The uMMA test is noninvasive (it is a urinalysis) and is a much more discrete test than a serum MMA.

The uMMA test is a functional assay. uMMA reflects cobalamin (Vitamin B12) activity at the tissue/cellular level since MMA levels are directly related to a B12-dependent metabolic pathway.

The conversion of MMA to succinic acid requires vitamin B12. The metabolic pathway for MMA is show in the photos below.

Vitamin B12 deficiency impedes this pathway and causes MMA levels to increase.  Thus, as water builds up behind a dam, high uMMA levels indicate a vitamin B12 deficiency.  

    To receive more information about the uMMA via email, please fill out the contact form below.  If you would prefer a telephone call, leave your telephone number, in what Time zone you are located and the best time to contact you by telephone in the comment section below.

Vitamin B-12 (also known as cobalamin) is generally found only in meat and dairy products. In combination with folic acid, B-12 is involved in DNA synthesis, production of the myelin sheath that protects nerves and red blood cell production. As a methyl donor involved in homocysteine metabolism, B-12 also plays an important role in immune and nerve function.

Following is a short list of who should be tested:

Anyone with:

  • Mental status changes
  • Neurologic or motor symptoms
  • Gastrointestinal surgery
  • Anemia or elevated MCV
  • Age 60 or over annually (or age 50 test every 5 years until age 65 annual testing 4A)
  • Under age 60 with unexplained neurologic symptoms
  • Strict vegetarian diet after one years on diet-- See discussion Preventable
  • Epidemic
  • Taking folate supplements
  • Exclusively breast fed infant of vegan mother or mother with pernicious anemia
  • (infant symptoms may include: irritability, anorexia, failure to thrive, lethargy, comatose, apathetic, anemia, hypotonia, developmental delay, hyperreflexia)
  • symptoms suggesting multiple sclerosis (MS)4A
  • Autoimmune disease
  • Chronic pancreatitis
  • Crohn's disease
  • Malabsorption syndromes
  • Use of histamine2 receptor antagonists or proton pump inhibitors
  • Thyroid disease

Neurologic Symptoms:
  • Paresthesia
  • Weakness or fatigue
  • Muscle aches
  • Impaired vibration or position sense
  • Impaired pain or touch perception
  • Ataxia
  • Abnormal gait
  • Decreased reflexes
  • Unexplained vision or taste impairment
  • Impotence
  • Urinary or fecal incontinence
  • Lhermitte's sign (sudden electric-like shocks down the spine on flexing head)
  • Positive Romberg's sign (increased unsteadiness on feet when eyes are closed)

Psychological Symptoms:

  • Memory loss
  • Disorientation
  • Apathy
  • Irritability
  • Paranoia
  • Depression
  • Hallucinations
  • Violent behavior
  • Psychosis
  • Personality changes
  • Dementia

uMMA test

$169.95 $169.95
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NOTE:   The above price reflects shipping and handling to addresses inside the contiguous (lower 48 adjoining states plus Washington, D.C.) of the U.S.A.

Additional shipping fees apply to Hawaii, Alaska, off shore American territories and possessions and to International orders.

uMMA test:

The uMMA test will reveal if the tissue is using B12.  The uMMA test is noninvasive (it is a simple urinalysis) and is a much more discrete test than a serum MMA.

The uMMA test is a functional assay. uMMA reflects cobalamin (Vitamin B12) activity at the tissue/cellular level since MMA levels are directly related to a B12-dependent metabolic pathway.

The conversion of MMA to succinic acid requires vitamin B12. The metabolic pathway for MMA is show in the photos below.

Vitamin B12 deficiency impedes this pathway and causes MMA levels to increase.  Thus, as water builds up behind a dam, high uMMA levels indicate a vitamin B12 deficiency.  


Medical practitioners and Alternative Health Clinics:

Please contact us via telephone or email and we will be pleased to set your facility up as an intake location for this critical test.